ABSTRACT
AIMS: To determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends. METHODS: Our study is based on diabetes manifestation data of the 0.5-<18-year-old children/adolescents from the German multicenter Diabetes Prospective Follow-up Registry. Based on long-term pre-pandemic trends from 2011 to 2019, we estimated adjusted incidence rate ratios (IRR) for T1D and DKA, and prevalence rate ratios (PRR) regarding autoantibody status with 95 % confidence intervals (CI) for the years 2020 and 2021 (observed versus predicted rates), using multivariable negative binomial or beta-binomial regression, respectively. RESULTS: We analyzed data of 30,840 children and adolescents with new-onset T1D. The observed incidences were significantly higher than the predicted incidences (IRR2020 1.13 [1.08-1.19]; IRR2021 1.20 [1.15-1.26]). The prevalence of autoantibody-negative diabetes did not change (PRR2020 0.91 [0.75-1.10]; PRR2021 1.03 [0.86-1.24]). The incidence of DKA during the pandemic was higher than predicted (IRR2020 1.34 [1.23-1.46]; IRR2021 1.37 [1.26-1.49]). CONCLUSIONS: An increase in the incidences of T1D and DKA, but not of autoantibody-negative diabetes was observed during both pandemic years. Further monitoring and efforts for DKA prevention at onset are necessary.
Subject(s)
COVID-19 , Diabetes Mellitus, Type 1 , Diabetic Ketoacidosis , Child , Humans , Adolescent , Diabetes Mellitus, Type 1/epidemiology , Diabetes Mellitus, Type 1/complications , Incidence , Pandemics , Prospective Studies , COVID-19/epidemiology , COVID-19/complications , Diabetic Ketoacidosis/etiology , Registries , Germany/epidemiologyABSTRACT
This book provides a global perspective on the transformations in the world of work caused by the COVID-19 pandemic. The collection of essays will break down the general statistics and trends into glimpses of concrete experiences of workers during pandemic, of workplaces transformed or destroyed, of workers protesting against political measures, of professions particularly exposed to the coronavirus, and also of the changing nature of some professions. © 2021 Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.